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Hodgkin lymphoma is a cancer of lymph tissue. Lymph tissue is found in the lymph nodes, spleen, liver, bone marrow, and other sites.
Lymphoma - Hodgkin; Hodgkin disease; Cancer - Hodgkin lymphoma
The cause of Hodgkin lymphoma is not known. Hodgkin lymphoma is most common among people 15 to 35 years old and 50 to 70 years old. Past infection with the Epstein-Barr virus (EBV) is thought to contribute to some cases. People with HIV infection are at increased risk compared to the general population.
The first sign of Hodgkin lymphoma is often a swollen lymph node that appears without a known cause. The disease can spread to nearby lymph nodes. Later it may spread to the spleen, liver, bone marrow, or other organs.
Symptoms may include any of the following:
Other symptoms that may occur with this disease:
Symptoms caused by Hodgkin lymphoma may occur with other conditions. Talk to your doctor about the meaning of your specific symptoms.
The doctor will perform a physical exam and check body areas with lymph nodes to feel if they are swollen.
The disease is often diagnosed after a biopsy of suspected tissue, usually a lymph node.
The following procedures will usually be done:
If tests show that you have Hodgkin lymphoma, more tests will be done to see how far the cancer has spread. This is called staging. Staging helps guide treatment and follow-up.
Treatment depends on the following:
High-dose chemotherapy may be given when Hodgkin lymphoma returns after treatment or does not respond to the first treatment. This is followed by a stem cell transplant that uses your own stem cells.
You and your health care provider may need to manage other concerns during your leukemia treatment, including:
You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences can help you not feel alone.
Hodgkin lymphoma is one of the most curable cancers. Cure is even more likely if it is diagnosed and treated early. Unlike other cancers, Hodgkin lymphoma is also very curable in its late stages.
You will need to have regular exams and imaging tests for years after your treatment. This helps your doctor check for signs of the cancer returning and for any long-term treatment effects.
Treatments for Hodgkin lymphoma can have complications. Long-term complications of chemotherapy or radiation therapy include:
Keep following up with a doctor who knows about monitoring and preventing these complications.
Call your provider if:
Bartlett NL, Foyli KV. Hodgkin lymphoma. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Abeloff's Clinical Oncology. 5th ed. Philadelphia, PA: Elsevier; 2014:chap 105.
National Cancer Institute: PDQ adult Hodgkin lymphoma treatment. Bethesda, MD: National Cancer Institute. Updated February 12, 2016. cancer.gov/cancertopics/pdq/treatment/adulthodgkins/HealthProfessional. Accessed March 17, 2016.
National Cancer Institute: PDQ childhood Hodgkin lymphoma treatment. Bethesda, MD: National Cancer Institute. Updated February 3, 2016. cancer.gov/cancertopics/pdq/treatment/childhodgkins/HealthProfessional. Accessed March 17, 2016.
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: Hodgkin lymphoma. Version 2.2015. www.nccn.org/professionals/physician_gls/pdf/hodgkins.pdf. Accessed March 17, 2016.
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.