Skip to Content
Allergic vasculitis is an extreme reaction to a drug, infection, or foreign substance. It leads to inflammation and damage to blood vessels of the skin.
Vasculitis - allergic; Hypersensitivity vasculitis; Cutaneous leukocytoclastic vasculitis
Allergic vasculitis is caused by an allergic reaction to a drug, an infection, or other foreign substance. It most often affects people older than age 15.
Often, the cause of the problem cannot be found even with a careful medical history.
Allerigic vasculitis may look like necrotizing vasculitis, which can affect blood vessels around the body.
The doctor will base the diagnosis on symptoms and the appearance of how your skin looks after you take a certain medicine or are exposed to a foreign substance (antigen).
The goal of treatment is to reduce inflammation.
Your health care provider may prescribe aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), or corticosteroids to reduce inflammation of the blood vessels. (DO NOT give aspirin to children except as advised by your health care provider.)
Your doctor may tell you to stop taking a medicine that could be causing this condition. Do not stop taking any medicine without first talking to your doctor.
Allergic vasculitis usually goes away over time. The condition may come back in some people.
People with ongoing vasculitis should be checked for necrotizing vasculitis.
Call your health care provider if you have symptoms of allergic vasculitis.
Do not take medicines which have caused an allergic reaction in the past.
Stone JH. Immune complex-mediated small vessel vasculitis. In: Firestein GS, Budd RC, Gabriel SE, et al, eds. Kelley's Textbook of Rheumatology. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2012:chap 91.
Reviewed By: Gordon A. Starkebaum, MD, Professor of Medicine, Division of Rheumatology, University of Washington School of Medicine. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.